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About us
Nerviano Medical Sciences S.r.l is focused on discovery and clinical development of small molecule NCEs for oncology. The company takes innovative approaches on novel mechanisms of action and drug targets to bring first- and best-in-class personalized medicines to cancer patients.
Our current pipeline consists of NCEs, which all originate from our well validated oncology drug discovery platform that span from early preclinical to clinical stage projects and which are being developed both in house and with partners.
Nerviano Medical Sciences S.r.l combines the flexibility of a biotech with the quality of a big pharma. Here, an experienced management team leads a highly skilled staff of professionals with global vision and a broad range of expertise in research, drug discovery and clinical development. We cover the whole range of additional aspects of drug development through the NMS Group affiliate companies, Accelera (AdMet) and NerPharma (manufacturing).
A key strength is our industrially renowned kinase inhibitor drug discovery platform which comprises an ever evolving chemical collection with broad intellectual property coverage, discovery know-how and technologies which enabled us to out-license IP rights on recently approved innovative medicines such as encorafenib and entrectinib. Moreover, we are also developing a proprietary payload platform for generation of novel Antibody-Drug Conjugates (ADCs).
We collaborate with academia and clinical investigators as well as with industrial partners worldwide to advance our programs from early discovery to clinical development of new drugs. We seek further strategic collaborations to develop and commercialize our products in different territories as well as in-licensing opportunies of promising assets for clinical development.
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Research
Our daily commitment

Research is the driving engine of our Company, with a longstanding experience in R&D and a proven track record of being able to perform innovative research and to bring molecules into clinical development up to registration.
Our research addresses different targets in key biological areas and molecular mechanisms that are crucial for onset and progression of diverse cancer types.
Our projects are supported by our scientific platforms, including the Kinase Platform and the ADC platform, that leverage our long standing expertise and technology approaches to generate economy of scale, allowing us to manage a broad project portfolio.
Clinical programs
We are exploiting our core Discovery engine to constantly develop new molecular entities with potential for “first in class” and “best in class”.
Our projects target a broad number of solid tumors and haematological indications, with a focus on biomarker selected patient populations. We are developing projects in house into clinical development in order to accelerate the clinical benefit for our patients.
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Pipeline
Our pipeline includes outlicensed molecules in advanced clinical stage or already registered, as well as a broad portfolio of molecules at preclinical and clinical stage that are being developed by Nerviano Medical Sciences in different indications.
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Latest News & Events
Nerviano Medical Sciences S.r.l. to present data on its ADC platform at the World ADC Summit 2023 in San Diego CA (Oct 16th-Oct 19th, 2023)
Nerviano Medical Sciences S.r.l., a member of NMS Group S.p.A and a clinical stage biotech discovering and developing innovative therapies for the treatment of cancer, is proud to announce its participation to the World ADC 2023 summit that will be held in San Diego (CA) from October 16th to October 19th, 2023, with two poster presentations
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Nerviano Medical Sciences Srl partecipa alla European Biotech Week 2023 / Nerviano Medical Sciences Srl participates in the European Biotech Week 2023
La EBW è una settimana di eventi e incontri in tutta Europa per raccontare le biotecnologie nei diversi settori di applicazione ad un pubblico vasto e diversificato, sottolineando il ruolo chiave che queste tecnologie hanno nel migliorare la qualità della vita di tutti noi.
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Nerviano Medical Sciences S.r.l. announces preclinical data on NMS-P945, its novel proprietary payload-linker for ADC generation, published in Molecular Cancer Therapeutics
Nerviano, September 20, 2023 – Nerviano Medical Sciences S.r.l. (NMS), a member of NMS Group S.p.A. and a clinical stage biotech, discovering and developing innovative therapies for the treatment of cancer, today announces the publication of preclinical data on NMS-P945 (link to article), its novel protease-cleavable thienoduocarmycin derivative payload-linker, with DNA damaging properties, in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.
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