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2022

BL-01, an Fc-bearing, tetravalent CD20 × CD5 bispecific antibody, redirects multiple immune cells to kill tumors in vitro and in vivo.

Interdonato A, Choblet S, Sana M, Valgardsdottir R, Cribioli S, Alzani R, Roth M, Duonor-Cerutti M, Golay J

Cytotherapy (2022), 24(2), 161-171

First-in-man, first-in-class phase I study with the monopolar spindle 1 kinase inhibitor S81694 administered intravenously in adult patients with advanced, metastatic solid tumours

Schöffski P, Awada A, de la Bigne A, Felloussi Z, Burbridge M, Cantero F, Colombo R, Maruzzelli S, Ammattatelli K, de Jonge M, Aftimos P, Dumez H, Sleijfer S

Eur J Cancer (2022), 169 (135-145)

A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response

Gambardella G, Viscido G, Tumaini B, Isacchi A, Bosotti R, di Bernardo D

Nat Commun (2022), 13(1), 1714

A randomized phase III study of fractionated docetaxel, oxaliplatin, capecitabine (low-tox) vs epirubicin, oxaliplatin and capecitabine (eox) in patients with locally advanced unresectable or metastatic gastric cancer: the lega trial

Rosati G, Cella CA, Cavanna L, Codecà C, Prisciandaro M, Mosconi S, Luchena G, Silvestris N, Bernardini I, Casaretti R, Zoratto F, Amoroso D, Ciarlo A, Barni S, Cascinu S, Davite C, Di Sanzo A, Casolaro A, Bilancia D, Labianca R

Gastric Cancer (2022), 25, 783–793

 

Development of an Effective Tumor-Targeted Contrast Agent for Magnetic Resonance Imaging Based on Mn/H-Ferritin Nanocomplexes

Tullio C, Salvioni L, Bellini M, Degrassi A, Fiandra L, D’Arienzo M, Garbujo S, Rotem R, Testa F, Prosperi D, Colombo M

ACS Appl Bio Mater (2021), 15, 4(11), 7800-7810

2021

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene. 

Fugazza C, Barbarani G, Elangovan S, Marini MG, Giolitto S, Font-Monclus I, Marongiu MF, Manunza L, Strouboulis J, Cantù C, Gasparri F, Barabino SML, Nakamura Y, Ottolenghi S, Moi P, Ronchi AE. 

Haematologica (2021), 106(2), 474-482

PHA-680626 Is an effective inhibitor of the interaction between Aurora-A and N-Myc.

Boi D, Souvalidou F, Capelli D, Polverino F, Marini G, Montanari R, Pochetti G, Tramonti A, Contestabile R, Trisciuoglio D, Carpinelli P, Ascanelli C, Lindon C, De Leo A, Saviano M, Di Santo R, Costi R, Guarguaglini G, Paiardini A

Int J Mol Sci (2021), 22(23), 13122

RNAdetector: a free user-friendly stand-alone and cloud-based system for RNA-Seq data analysis

La Ferlita A, Alaimo S, Di Bella S, Martorana E, Laliotis G, Bertoni F, Cascione L, Tsichlis P, Ferro A, Bosotti R, Pulvirenti A

BMC Bioinformatics (2021), volume 22, Article number: 298

EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors

Capone E, Lattanzio R, Gasparri F, Orsini P, Rossi C, Iacobelli V, De Laurenzi V, Natali PG, Valsasina B, Iacobelli S, Sala GL

Pharmaceutics (2021), 13(4), 483

Identification of unprecedented ATP-competitive choline kinase inhibitors

Quartieri F, Nesi M, Avanzi N,  Borghi D, Casale E, Corti  E, Cucchi  U, Donati D,  Fasolini M, Felder  E, Galvani A, Giorgini  ML, Lomolino  A, Menichincheri  M,  Orrenius  C, Perrera  C, Re Depaolini  S, Riccardi-Sirtori F, Salsi E,  Isacchi  A,  Gnocchi  P

Bioorg Med Chem Lett (2021), 51, 128310

2020

A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data.Brief Bioinform.

Di Bella S, La Ferlita A, Carapezza G, Alaimo S, Isacchi A, Ferro A, Pulvirenti A, Bosotti R.

2020 Dec 1;21(6):1987-1998. doi: 10.1093/bib/bbz110. PMID: 31740918

Mining potentially actionable kinase gene fusions in cancer cell lines with the KuNG FU database.

Somaschini A, Di Bella S, Cusi C, Raddrizzani L, Leone A, Carapezza G, Mazza T, Isacchi A, Bosotti R.  Sci Data.

2020 Nov 30;7(1):420. doi: 10.1038/s41597-020-00761-2. PMID: 33257674; PMCID: PMC7705673.

A phase II trial of bendamustine in combination with ofatumumab in patients with relapsed or refractory marginal zone B-cell lymphomas.

Vannata B, Vanazzi A, Negri M, Liptrott SJ, Bartosek AA, Miani M, Di Sanzo A, Cavalli F, Zucca E, Stathis A.

Hematol Oncol. 2020 Oct 26. doi: 10.1002/hon.2822. Epub ahead of print. PMID: 33103778.

Entrectinib approval by EMA reinforces options for ROS1 and tumour agnostic NTRK targeted cancer therapies.

Ardini E, Siena S.

ESMO Open. 2020 Sep;5(5):e000867. doi: 10.1136/esmoopen-2020-000867. PMID: 32907817; PMCID:PMC7481078.

Increased tumor burden in patients with chronic myeloid leukemia after 36 months of imatinib discontinuation.

Diral E, Mori S, Antolini L, Abruzzese E, Le Coutre P, Martino B, Pungolino E, Elena C, Bergamaschi M, Assouline S, Di Bona E, Gozzini A, Andrade-Campos M, Stagno F, Iurlo A, Pirola A, Fontana D, Petiti J, Bonanomi ML, Crivori P, Piazza R, Fava C, Gambacorti-Passerini C.

Blood. 2020 Nov 5;136(19):2237-2240. doi: 10.1182/blood.2019004371. PMID: 32518953.

2019

Comprehensive kinome NGS targeted expression profiling by KING-REX
Carapezza G, Cusi C, Rizzo E, Raddrizzani L, Di Bella S, Somaschini A, Leone A, Lupi R, Mutarelli M, Nigro V, di Bernardo D, Magni P, Isacchi A, Bosotti R
BMC Genomics (2019), 20(1), 307

Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515
Gianluca Papeo,* Paolo Orsini, Nilla R. Avanzi, Daniela Borghi, Elena Casale, Marina Ciomei,
Alessandra Cirla, Viviana Desperati,† Daniele Donati, Eduard R. Felder, Arturo Galvani, Marco Guanci,‡
Antonella Isacchi, Helena Posteri, Sonia Rainoldi, Federico Riccardi-Sirtori,§ Alessandra Scolaro,∥
and Alessia Montagnoli
ACS Medicinal Chemistry Letters 2019

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
Sano R, Krytska K, Larmour CE, Raman P, Martinez D, Ligon GF, Lillquist JS, Cucchi U, Orsini P, Rizzi S, Pawel BR, Alvarado D, Mossé YP
Sci Transl Med (2019), 11(483)

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate.
Raposo Moreira Dias A, Pina A, Dean A, Lerchen HG, Caruso M, Gasparri F, Fraietta I, Troiani S, Arosio D, Belvisi L, Pignataro L, Dal Corso A, Gennari C
Chemistry (2019), 25(7), 1696-1700

A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data
Di Bella S, La Ferlita A, Carapezza G, Alaimo S, Isacchi A, Ferro A, Pulvirenti A, Bosotti R.
Brief Bioinform (2019), Nov 18 [Epub ahead of print]

Investigating miRNA-IncRNA interactions: Computational tools and resources
Veneziano D, Marceca GP, Di Bella S, Nigita G, Distefano R, Croce CM
Methods Mol Biol (2019), 1970 (Chapt 14), 251-277

Drug-Initiated synthesis of heterotelechelic polymer prodrug nanoparticles for in vivo imaging and cancer cell targeting
Vinciguerra D, Degrassi A, Mancini L, Mura S, Mougin J, Couvreur P, Nicolas J
Biomacromolecules (2019), 20(7), 2464-2476

Mechanism of action of the tumor vessel targeting agent NGR-hTNF: Role of both NGR peptide and hTNF in cell binding and signaling
Valentinis B, Porcellini S, Asperti C, Cota M, Zhou D, Di Matteo P, Garau G, Zucchelli C, Avanzi NR, Rizzardi GP, Degano M, Musco G, Traversari C
Int J Mol Sci (2019), 20(18), 4511-4533

History

People/Team

Mission, Vision and Values
Collaboration and Partnership
Financials
MSCA Detrimode Project
History

People/Team

Mission, Vision and Values
Collaboration and Partnership
Financials
MSCA Detrimode Project

 

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