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2021

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene. 

Fugazza C, Barbarani G, Elangovan S, Marini MG, Giolitto S, Font-Monclus I, Marongiu MF, Manunza L, Strouboulis J, Cantù C, Gasparri F, Barabino SML, Nakamura Y, Ottolenghi S, Moi P, Ronchi AE. 

Haematologica (2021), 106(2), 474-482

2020

A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data.Brief Bioinform.

Di Bella S, La Ferlita A, Carapezza G, Alaimo S, Isacchi A, Ferro A, Pulvirenti A, Bosotti R.

2020 Dec 1;21(6):1987-1998. doi: 10.1093/bib/bbz110. PMID: 31740918

Mining potentially actionable kinase gene fusions in cancer cell lines with the KuNG FU database.

Somaschini A, Di Bella S, Cusi C, Raddrizzani L, Leone A, Carapezza G, Mazza T, Isacchi A, Bosotti R.  Sci Data.

2020 Nov 30;7(1):420. doi: 10.1038/s41597-020-00761-2. PMID: 33257674; PMCID: PMC7705673.

A phase II trial of bendamustine in combination with ofatumumab in patients with relapsed or refractory marginal zone B-cell lymphomas.

Vannata B, Vanazzi A, Negri M, Liptrott SJ, Bartosek AA, Miani M, Di Sanzo A, Cavalli F, Zucca E, Stathis A.

Hematol Oncol. 2020 Oct 26. doi: 10.1002/hon.2822. Epub ahead of print. PMID: 33103778.

Entrectinib approval by EMA reinforces options for ROS1 and tumour agnostic NTRK targeted cancer therapies.

Ardini E, Siena S.

ESMO Open. 2020 Sep;5(5):e000867. doi: 10.1136/esmoopen-2020-000867. PMID: 32907817; PMCID:PMC7481078.

Increased tumor burden in patients with chronic myeloid leukemia after 36 months of imatinib discontinuation.

Diral E, Mori S, Antolini L, Abruzzese E, Le Coutre P, Martino B, Pungolino E, Elena C, Bergamaschi M, Assouline S, Di Bona E, Gozzini A, Andrade-Campos M, Stagno F, Iurlo A, Pirola A, Fontana D, Petiti J, Bonanomi ML, Crivori P, Piazza R, Fava C, Gambacorti-Passerini C.

Blood. 2020 Nov 5;136(19):2237-2240. doi: 10.1182/blood.2019004371. PMID: 32518953.

2019

Comprehensive kinome NGS targeted expression profiling by KING-REX
Carapezza G, Cusi C, Rizzo E, Raddrizzani L, Di Bella S, Somaschini A, Leone A, Lupi R, Mutarelli M, Nigro V, di Bernardo D, Magni P, Isacchi A, Bosotti R
BMC Genomics (2019), 20(1), 307

Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515
Gianluca Papeo,* Paolo Orsini, Nilla R. Avanzi, Daniela Borghi, Elena Casale, Marina Ciomei,
Alessandra Cirla, Viviana Desperati,† Daniele Donati, Eduard R. Felder, Arturo Galvani, Marco Guanci,‡
Antonella Isacchi, Helena Posteri, Sonia Rainoldi, Federico Riccardi-Sirtori,§ Alessandra Scolaro,∥
and Alessia Montagnoli
ACS Medicinal Chemistry Letters 2019

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
Sano R, Krytska K, Larmour CE, Raman P, Martinez D, Ligon GF, Lillquist JS, Cucchi U, Orsini P, Rizzi S, Pawel BR, Alvarado D, Mossé YP
Sci Transl Med (2019), 11(483)

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate.
Raposo Moreira Dias A, Pina A, Dean A, Lerchen HG, Caruso M, Gasparri F, Fraietta I, Troiani S, Arosio D, Belvisi L, Pignataro L, Dal Corso A, Gennari C
Chemistry (2019), 25(7), 1696-1700

A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data
Di Bella S, La Ferlita A, Carapezza G, Alaimo S, Isacchi A, Ferro A, Pulvirenti A, Bosotti R.
Brief Bioinform (2019), Nov 18 [Epub ahead of print]

Investigating miRNA-IncRNA interactions: Computational tools and resources
Veneziano D, Marceca GP, Di Bella S, Nigita G, Distefano R, Croce CM
Methods Mol Biol (2019), 1970 (Chapt 14), 251-277

Drug-Initiated synthesis of heterotelechelic polymer prodrug nanoparticles for in vivo imaging and cancer cell targeting
Vinciguerra D, Degrassi A, Mancini L, Mura S, Mougin J, Couvreur P, Nicolas J
Biomacromolecules (2019), 20(7), 2464-2476

Mechanism of action of the tumor vessel targeting agent NGR-hTNF: Role of both NGR peptide and hTNF in cell binding and signaling
Valentinis B, Porcellini S, Asperti C, Cota M, Zhou D, Di Matteo P, Garau G, Zucchelli C, Avanzi NR, Rizzardi GP, Degano M, Musco G, Traversari C
Int J Mol Sci (2019), 20(18), 4511-4533

History
People/Team
Mission, Vision and Values
Governance and Compliance
Collaboration and Partnership
Financials
MSCA Detrimode Project
History
People/Team
Mission, Vision and Values
Governance and Compliance
Collaboration and Partnership
Financials
MSCA Detrimode Project

 

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