Nerviano Medical Sciences attended the 16th Annual Meeting of the Bioinformatics Italian Society (BITS). It is a nonprofit scientific society aimed at favoring the interactions and the scientific and technological exchange among researchers involved in Bioinformatics field, coordinated by a Steering Committee where a researcher from Nerviano Medical Sciences is a Councilor.
The conference, held in June in Palermo, highlights keynote talks in bioinformatics and its applications and presentations of state-of-the-art research in computational biology. Nerviano Medical Sciences contributed with three posters related to a new interactive database on kinase gene fusions, the development of a comprehensive RNA-seq pipeline for RNA and non-coding RNA gene expression analysis and the implementation of a new NGS-based panel dedicated to gene expression analysis of the whole kinome.
A new interactive database containing the largest homogeneous, manually curated and functionally annotated dataset of experimentally validated kinase fusions in cancer cell lines was the theme of the first presentation. This database, through a query search panel, allows the users to access, filter, select and retrieve kinase fusion events together with information on the cancer cell lines in which they occur. It represents the starting point for further downstream dry and wet-lab analyses, facilitating cancer research and drug discovery processes.
A second presentation described the development of a comprehensive RNA-seq pipeline for RNA and non-coding RNA gene expression analysis, a cross-platform pipeline providing a reliable, flexible, and easy-to-use interface for the analysis of all known coding and non-coding RNAs.
The implementation of a new NGS-based panel dedicated to gene expression analysis of the whole kinome was presented in the third poster. The characterization of chordoma cell lines was reported as an example of application of this technology (Comprehensive kinome NGS targeted expression profiling by KING-REX, BMC Genomics. 2019 Apr 23; 20(1):307, Carapezza G. et al.)
The presented activities are in the frame of the Nerviano Medical Sciences implementation of new genomics and bioinformatics approaches for the identification of new targets and new biomarkers in support to drug development.