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Pubblicazioni 2014

2014

 

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors
Cervi G, Magnaghi P, Asa D, Avanzi N, Badari A, Borghi D, Caruso M, Cirla A, Cozzi L, Felder E, Galvani A, Gasparri F, Lomolino A, Magnuson S, Malgesini B, Motto I, Pasi M, Rizzi S, Salom B, Sorrentino G, Troiani S, Valsasina B, O’Brien T, Isacchi A, Donati D, D’Alessio R
J Med Chem (2014), 57(24),10443-54
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Drug resistance
Texidó G, Moll J.
Drug Discov Today Technol (2014), 11, 1-3
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Direct involvement of CD56 in CIK-mediated lysis of CD56+ hematopoietic target cells
Valgardsdottir R, Capitanio C, Texido G, Pende D, Cantoni C, Pesenti E, Rambaldi A, Golay J, Introna M.
Exp Hematol. (2014), [Epub ahead of print]
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A novel method using blinatumomab for efficient, clinical-grade expansion of polyclonal T cells for adoptive immunotherapy
Golay J, D’Amico A, Borleri G, Bonzi M, Valgardsdottir R, Alzani R, Cribioli S, Albanese C, Pesenti E, Finazzi MC, Quaresmini G, Nagorsen D, Introna M, Rambaldi A.
J Immunol. (2014), 193(9), 4739-47
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The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition
Ardini E, Bosotti R, Borgia AL, De Ponti C, Somaschini A, Cammarota R, Amboldi N, Raddrizzani L, Milani A, Magnaghi P, Ballinari D, Casero D, Gasparri F, Banfi P, Avanzi N, Saccardo MB, Alzani R, Bandiera T, Felder E, Donati D, Pesenti E, Sartore-Bianchi A, Gambacorta M, Pierotti MA, Siena S, Veronese S, Galvani A, Isacchi A.
Mol Oncol. (2014), 8(8), 1495-507
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Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance
Sero V, Tavanti E, Vella S, Hattinger CM, Fanelli M, Michelacci F, Versteeg R, Valsasina B, Gudeman B, Picci P, Serra M
Invest New Drugs. (2014) 32(6), 1167-80
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Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors
Casale E, Amboldi N, Brasca MG, Caronni D, Colombo N, Dalvit C, Felder ER, Fogliatto G, Galvani A, Isacchi A, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Casuscelli F.
Bioorg Med Chem. (2014), 22(15), 4135-50
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Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
Brasca MG, Nesi M, Avanzi N, Ballinari D, Bandiera T, Bertrand J, Bindi S, Canevari G, Carenzi D, Casero D, Ceriani L, Ciomei M, Cirla A, Colombo M, Cribioli S, Cristiani C, Della Vedova F, Fachin G, Fasolini M, Felder ER, Galvani A, Isacchi A, Mirizzi D, Motto I, Panzeri A, Pesenti E, Vianello P, Gnocchi P, Donati D.
Bioorg Med Chem. (2014), 22(14), 4998-5012
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Vascular Endothelial Growth Factor C Promotes Ovarian Carcinoma Progression through Paracrine and Autocrine Mechanisms
Decio A, Taraboletti G, Patton V, Alzani R, Perego P, Fruscio R, Jürgensmeier JM, Giavazzi R, Belotti D.
Am J Pathol. (2014) 184(4), 1050-61
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Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS1 Kinase Inhibitor NMS-P715
Slee RB, Grimes BR, Bansal R, Gore J, Blackburn C, Brown L, Gasaway R, Jeong J, Victorino J, March KL, Colombo R, Herbert BS, Korc M.
Mol Cancer Ther (2014), 13(2), 307-15
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Highly multiplexed phenotypic imaging for cell proliferation studies
Cappella P, Gasparri F.
J Biomol Screen (2014), 19(1), 145-57
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New resistance mechanisms for small molecule kinase inhibitors of Abl kinase Review Article
Modugno M
Drug Discovery Today: Technologies (2014), 11, 5-10
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Accuracy of 2-hydroxyglutarate quantification by short-echo proton-MRS at 3 T: A phantom study
Bertolino N, Marchionni C, Ghielmetti F, Burns B, Finocchiaro G, Anghileri E, Bruzzone MG, Minati L.
Phys Med. (2014), 30(6), 702-7
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Insights into PARP Inhibitors’ Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays
Papeo G, Avanzi N, Bettoni S, Leone A, Paolucci M, Perego R, Quartieri F, Riccardi-Sirtori F, Thieffine S, Montagnoli A, Lupi R.
J Biomol Screen. (2014), 19 (8), 1212-1219
View abstract on PubMed