HomeDiscoveryPubblicazioniPubblicazioni 2013

Pubblicazioni 2013

2013

 

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds
Calogero F, Borrelli S, Speciale G, Christodoulou MS, Cartelli D, Ballinari D, Sola F, Albanese C, Ciavolella A, Passarella D, Cappelletti G, Pieraccini S, Sironi M
ChemPlusChem (2013), 78(7), 663–669

Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity
Sancineto L, Iraci N, Massari S, Attanasio V, Corazza G, Barreca ML, Sabatini S, Manfroni G, Avanzi NR, Cecchetti V, Pannecouque C, Marcello A, Tabarrini O.
ChemMedChem (2013), 8(12), 1941-53
View abstract on PubMed

Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin
Sabatino MA, Geroni C, Ganzinelli M, Ceruti R, Broggini M.
Epigenetics (2013), 8(6), 656-65
View abstract on PubMed

Italian chemists’ contributions to named reactions in organic synthesis: an historical perspective
Papeo G, Pulici M.
Molecules (2013), 8(9), 10870-900
View abstract on PubMed

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)
Brasca MG, Mantegani S, Amboldi N, Bindi S, Caronni D, Casale E, Ceccarelli W, Colombo N, De Ponti A, Donati D, Ermoli A, Fachin G, Felder ER, Ferguson RD, Fiorelli C, Guanci M, Isacchi A, Pesenti E, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Fogliatto G.
Bioorg Med Chem. (2013), 21(22), 7047-63
View abstract on PubMed

Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases
Casuscelli F, Ardini E, Avanzi N, Casale E, Cervi G, D’Anello M, Donati D, Faiardi D, Ferguson RD, Fogliatto GP, Galvani A, Marsiglio A, Mirizzi D, Montemartini M, Orrenius C, Papeo G, Piutti C, Salom B, Felder ER
Bioorganic & Medicinal Chemistry (2013), 21(23), 7364-80
Sciencedirect

The Piancatelli rearrangement: new applications for an intriguing reaction
Piutti C, Quartieri F
Molecules (2013), 18, 12290-12312

Diffuse scaling dermatitis in an athymic nude mouse.
Russo M, Invernizzi A, Gobbi A, Radaelli E.
Vet Pathol. (2013), 50(4), 722-6
View abstract on PubMed

Structural insight into maternal embryonic leucine zipper kinase (MELK) conformation and inhibition toward structure-based drug design
Canevari G, Re Depaolini S, Cucchi U, Bertrand JA, Casale E, Perrera C, Forte B, Carpinelli P, Felder ER
Biochemistry (2013), 52(37), 6380-7
View abstract on PubMed

From “Click” to “Fenton” chemistry for 5-bromo-2′-deoxyuridine determination
Cappella P, Giansanti V, Pulici M, Gasparri F.
Cytometry A (2013), 83(11), 989-1000
View abstract on PubMed

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
Magnaghi P, D’Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, Gasparri F, Cozzi L, Cucchi U, Orrenius C, Polucci P, Ballinari D, Perrera C, Leone A, Galvani A, Donati D, O’Brien T, Jackson P, Isacchi A
Nature Chem Biol (2013), 9, 548–556

NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases
Fogliatto G, Gianellini L, Brasca MG, Casale E, Ballinari D, Ciomei M, Degrassi A, De Ponti A, Germani M, Guanci M, Paolucci M, Polucci P, Russo M, Sola F, Valsasina B, Visco C, Zuccotto F, Donati D, Felder ER, Pesenti E, Galvani A, Mantegani S, Isacchi A.
Clin Cancer Res. (2013), 19(13), 3520-32
View abstract on PubMed

The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56(+) Acute Monoblastic Leukaemia.
Casolaro A, Golay J, Albanese C, Ceruti R, Patton V, Cribioli S, Pezzoni A, Losa M, Texido G, Giussani U, Marchesi F, Amboldi N, Valsasina B, Bungaro S, Cazzaniga G, Rambaldi A, Introna M, Pesenti E, Alzani R.
PLoS One. (2013), 8(3), e58424
View abstract on PubMed

PARP inhibitors in cancer therapy: an update
Papeo G, Casale E, Montagnoli A, Cirla A
Expert Opin Ther Pat. (2013), 23(4), 503-14
View abstract on PubMed

Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure-Activity Relationships
Polucci P, Magnaghi P, Angiolini M, Asa D, Avanzi N, Badari A, Bertrand J, Casale E, Cauteruccio S, Cirla A, Cozzi L, Galvani A, Jackson PK, Liu Y, Magnuson S, Malgesini B, Nuvoloni S, Orrenius C, Sirtori FR, Riceputi L, Rizzi S, Trucchi B, O’Brien T, Isacchi A, Donati D, D’Alessio R
J Med Chem (2013) 56(2), 437-450
View abstract on PubMed

RET inhibition: implications in cancer therapy
Borrello MG, Ardini E, Locati LD, Greco A, Licitra L, Pierotti MA
Expert Opin Ther Targets (2013), 17(4), 403-19
View abstract on PubMed

Cell line identity finding by fingerprinting, an optimized resource for short tandem repeat profile authentication
Somaschini A, Amboldi N, Nuzzo A, Scacheri E, Ukmar G, Ballinari D, Malyszko J, Raddrizzani L, Landonio A, Gasparri F, Galvani A, Isacchi A, Bosotti R
Genet Test Mol Biomarkers, (2013), 17(3), 254-9
View abstract on PubMed

In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
Mazzoletti M, Texido G
Methods Mol Biol (2013), 986, 325-37
View abstract on PubMed

Genetically engineered animal models for in vivo target identification and validation in oncology
Texido G
Methods Mol Biol (2013), (986), 281-305
View abstract on PubMed

Antitumor efficacy on glioma models of PHA-848125, a multikinase inhibitor able to cross the blood brain barrier
Albanese C, Alzani R, Amboldi N, Degrassi A, Festuccia C, Fiorentini F, Gravina GL, Mercurio C, Pastori W, Brasca MG, Pesenti E, Galvani A, Ciomei M
Br J Pharmacol. (2013), 169(1), 156-66
View abstract on PubMed